Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics

Mitochondrial transcription factor A (TFAM) is essential for the replication, transcription and maintenance of mitochondrial DNA (mtDNA). The role of TFAM in non-small cell lung cancer (NSCLC) remains largely unknown. Herein, we report that downregulation of TFAM in NSCLC cells resulted in cell cycl...

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Publicat a:Oncotarget
Autors principals: Xie, Deyao, Wu, Xiaoyi, Lan, Linhua, Shangguan, Fugeng, Lin, Xiaoming, Chen, Fuhong, Xu, Shan, Zhang, Ya, Chen, Zilei, Huang, Kate, Wang, Rongrong, Wang, Lu, Song, Xiaoxiao, Liu, Yongzhang, Lu, Bin
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905497/
https://ncbi.nlm.nih.gov/pubmed/26820294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7018
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