Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer

ATP-dependent Lon protease within mitochondrial matrix contributes to the degradation of abnormal proteins. The oxidative or hypoxic stress which represents the stress phenotype of cancer leads to up-regulation of Lon. However, the role of Lon in bladder cancer remains undefined. Here, we found that...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Liu, Yongzhang, Lan, Linhua, Huang, Kate, Wang, Rongrong, Xu, Cuicui, Shi, Yang, Wu, Xiaoyi, Wu, Zhi, Zhang, Jiliang, Chen, Lin, Wang, Lu, Yu, Xiaomin, Zhu, Haibo, Lu, Bin
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294382/
https://ncbi.nlm.nih.gov/pubmed/25526030
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