Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells

Acinar-to-ductal metaplasia (ADM) occurring in cerulein-mediated pancreatitis or in oncogenic Kras-driven pancreatic cancer development is accompanied by extensive changes in the transcriptional program. In this process, acinar cells shut down the expression of acinar specific differentiation genes...

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Опубликовано в: :Oncotarget
Главные авторы: Benitz, Simone, Regel, Ivonne, Reinhard, Tobias, Popp, Anna, Schäffer, Isabell, Raulefs, Susanne, Kong, Bo, Esposito, Irene, Michalski, Christoph W., Kleeff, Jörg
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905483/
https://ncbi.nlm.nih.gov/pubmed/26716510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6717
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