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When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer

The APOBEC3 cytidine deaminases play an important role in innate immunity but have also emerged as mediators of somatic mutations in human cancer. We recently reported a high incidence of APOBEC-mediated driver mutations in human papillomavirus-associated cancer, suggesting a key role for these enzy...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Henderson, Stephen, Chakravarthy, Ankur, Fenton, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905184/
https://ncbi.nlm.nih.gov/pubmed/27308321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mco.29914
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