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Do changes in the c-MYC coding sequence contribute to tumorigenesis?

The role of changes in the c-MYC coding sequence in cancer is controversial. Overexpression of wild-type protein is sufficient to drive tumorigenesis, yet point mutations in c-MYC are common in Burkitt's lymphoma. Our discovery that disparate tumor-associated mutations in c-MYC have similar pro...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Oncol
Prif Awduron: Chakraborty, Abhishek A., Tansey, William P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904990/
https://ncbi.nlm.nih.gov/pubmed/27308414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.965631
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