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Widespread microRNA repression by Myc contributes to tumorigenesis
The c-Myc oncogenic transcription factor (Myc) is pathologically activated in many human malignancies. Myc is known to directly upregulate a pro-tumorigenic group of microRNAs (miRNAs) known as the miR-17-92 cluster. Through the analysis of human and mouse models of B cell lymphoma, we show here tha...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628762/ https://ncbi.nlm.nih.gov/pubmed/18066065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2007.30 |
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