Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

Direct control of microRNA (miRNA) expression by oncogenic and tumor suppressor networks results in frequent dysregulation of miRNAs in cancer cells and contributes to tumorigenesis. We previously demonstrated that activation of the c-Myc oncogenic transcription factor (Myc) broadly influences miRNA...

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Bibliographic Details
Main Authors: Chang, Tsung-Cheng, Zeitels, Lauren R., Hwang, Hun-Way, Chivukula, Raghu R., Wentzel, Erik A., Dews, Michael, Jung, Jason, Gao, Ping, Dang, Chi V., Beer, Michael A., Thomas-Tikhonenko, Andrei, Mendell, Joshua T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651245/
https://ncbi.nlm.nih.gov/pubmed/19211792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808300106
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