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Activation of Transferrin Receptor 1 by c-Myc Enhances Cellular Proliferation and Tumorigenesis
Overexpression of transferrin receptor 1 (TFRC1), a major mediator of iron uptake in mammalian cells, is a common feature of human malignancies. Therapeutic strategies designed to interfere with tumor iron metabolism have targeted TFRC1. The c-Myc oncogenic transcription factor stimulates proliferat...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1430295/ https://ncbi.nlm.nih.gov/pubmed/16508012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.6.2373-2386.2006 |
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