Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment

The PI3K/AKT/mTOR signaling is important for cell proliferation, survival, and metabolism. Hyperactivation of this pathway is one of the most common signaling abnormalities observed in cancer and a substantial effort has recently been made to develop molecules targeting this signaling cascade. Howev...

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Bibliografiska uppgifter
I publikationen:Mol Cell Oncol
Huvudupphovsmän: Castel, Pau, Toska, Eneda, Zumsteg, Zachary S, Carmona, F Javier, Elkabets, Moshe, Bosch, Ana, Scaltriti, Maurizio
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2014
Ämnen:
Review
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904898/
https://ncbi.nlm.nih.gov/pubmed/27308344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.963447
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