Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation

Eosinophils are white blood cells that function in innate immunity and participate in the pathogenesis of various inflammatory and neoplastic disorders. Their secretory granules contain four cytotoxic proteins, including the eosinophil major basic protein (MBP-1). How MBP-1 toxicity is controlled wi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Soragni, Alice, Yousefi, Shida, Stoeckle, Christina, Soriaga, Angela B., Sawaya, Michael R., Kozlowski, Evelyne, Schmid, Inès, Radonjic-Hoesli, Susanne, Boutet, Sebastien, Williams, Garth J., Messerschmidt, Marc, Seibert, M. Marvin, Cascio, Duilio, Zatsepin, Nadia A., Burghammer, Manfred, Riekel, Christian, Colletier, Jacques-Philippe, Riek, Roland, Eisenberg, David, Simon, Hans-Uwe
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904734/
https://ncbi.nlm.nih.gov/pubmed/25728769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.026
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