Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation

Eosinophils are white blood cells that function in innate immunity and participate in the pathogenesis of various inflammatory and neoplastic disorders. Their secretory granules contain four cytotoxic proteins, including the eosinophil major basic protein (MBP-1). How MBP-1 toxicity is controlled wi...

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Publicado no:Mol Cell
Main Authors: Soragni, Alice, Yousefi, Shida, Stoeckle, Christina, Soriaga, Angela B., Sawaya, Michael R., Kozlowski, Evelyne, Schmid, Inès, Radonjic-Hoesli, Susanne, Boutet, Sebastien, Williams, Garth J., Messerschmidt, Marc, Seibert, M. Marvin, Cascio, Duilio, Zatsepin, Nadia A., Burghammer, Manfred, Riekel, Christian, Colletier, Jacques-Philippe, Riek, Roland, Eisenberg, David, Simon, Hans-Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904734/
https://ncbi.nlm.nih.gov/pubmed/25728769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.026
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