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Deconvolution of Ensemble Chromatin Interaction Data Reveals the Latent Mixing Structures in Cell Subpopulations

Chromosome conformation capture (3C) experiments provide a window into the spatial packing of a genome in three dimensions within the cell. This structure has been shown to be correlated with gene regulation, cancer mutations, and other genomic functions. However, 3C provides mixed measurements on a...

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Publicat a:J Comput Biol
Autors principals: Sefer, Emre, Duggal, Geet, Kingsford, Carl
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904159/
https://ncbi.nlm.nih.gov/pubmed/27267775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cmb.2015.0210
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