Diversity of the murine antibody response targeting influenza A(H1N1pdm09) hemagglutinin

We infected mice with the 2009 influenza A pandemic virus (H1N1pdm09), boosted with an inactivated vaccine, and cloned immunoglobulins (Igs) from HA-specific B cells. Based on the redundancy in germline gene utilization, we inferred that between 72–130 unique IgH VDJ and 35 different IgL VJ combinat...

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Publicat a:Virology
Autors principals: Wilson, Jason R., Tzeng, Wen-Pin, Spesock, April, Music, Nedzad, Guo, Zhu, Barrington, Robert, Stevens, James, Donis, Ruben O., Katz, Jacqueline M., York, Ian A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904151/
https://ncbi.nlm.nih.gov/pubmed/24928044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.04.011
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