Interferon-γ–Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome

Goblet cells (GCs) are specialized secretory cells that produce mucins and a variety of other proteins. Significant conjunctival GC loss occurs in both experimental dry eye models and patients with keratoconjunctivitis sicca due to the induction of interferon (IFN)-γ. With the use of a primary murin...

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Publicat a:Am J Pathol
Autors principals: Coursey, Terry G., Tukler Henriksson, Johanna, Barbosa, Flavia L., de Paiva, Cintia S., Pflugfelder, Stephen C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2016
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901135/
https://ncbi.nlm.nih.gov/pubmed/27085137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.02.004
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