REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

Hedgehog signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors. Allelic loss of chromosome 17p has also been described as the most frequent genetic defect in this human neoplasia. This observation raises th...

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Detalhes bibliográficos
Main Authors: Di Marcotullio, Lucia, Ferretti, Elisabetta, De Smaele, Enrico, Argenti, Beatrice, Mincione, Claudia, Zazzeroni, Francesca, Gallo, Rita, Masuelli, Laura, Napolitano, Maddalena, Maroder, Marella, Modesti, Andrea, Giangaspero, Felice, Screpanti, Isabella, Alesse, Edoardo, Gulino, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC490020/
https://ncbi.nlm.nih.gov/pubmed/15249678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400690101
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