The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1

A coding polymorphism of human ATG16L1 (rs2241880; T300A) increases the risk of Crohn's disease and it has been shown to enhance susceptibility of ATG16L1 to caspase cleavage. Here we show that T300A also alters the ability of the C-terminal WD40-repeat domain of ATG16L1 to interact with an ami...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Boada-Romero, Emilio, Serramito-Gómez, Inmaculada, Sacristán, María P., Boone, David L., Xavier, Ramnik J., Pimentel-Muiños, Felipe X.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899871/
https://ncbi.nlm.nih.gov/pubmed/27273576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11821
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