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The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1
A coding polymorphism of human ATG16L1 (rs2241880; T300A) increases the risk of Crohn's disease and it has been shown to enhance susceptibility of ATG16L1 to caspase cleavage. Here we show that T300A also alters the ability of the C-terminal WD40-repeat domain of ATG16L1 to interact with an ami...
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| Gepubliceerd in: | Nat Commun |
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| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4899871/ https://ncbi.nlm.nih.gov/pubmed/27273576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11821 |
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