Unconventional autophagy mediated by the WD40 domain of ATG16L1 is derailed by the T300A Crohn disease risk polymorphism

A coding polymorphism of the critical autophagic effector ATG16L1 (T300A) increases the risk of Crohn disease, but how this mutation influences the function of ATG16L1 has remained unclear. In a recent report, we showed that the A300 allele alters the ability of the C-terminal WD40 domain of ATG16L1...

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Detalles Bibliográficos
Publicado en:Autophagy
Autores principales: Serramito-Gómez, Inmaculada, Boada-Romero, Emilio, Pimentel-Muiños, Felipe X.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
Materias:
Autophagic Punctum
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103359/
https://ncbi.nlm.nih.gov/pubmed/27541200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1216303
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