Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver

Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clea...

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izdano v:Sci Rep
Main Authors: Nakabori, Tasuku, Hikita, Hayato, Murai, Kazuhiro, Nozaki, Yasutoshi, Kai, Yugo, Makino, Yuki, Saito, Yoshinobu, Tanaka, Satoshi, Wada, Hiroshi, Eguchi, Hidetoshi, Takahashi, Takeshi, Suemizu, Hiroshi, Sakamori, Ryotaro, Hiramatsu, Naoki, Tatsumi, Tomohide, Takehara, Tetsuo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899802/
https://ncbi.nlm.nih.gov/pubmed/27278060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27782
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