Hepatitis C virus enhances Rubicon expression, leading to autophagy inhibition and intracellular innate immune activation

Autophagy, a degradation system, works to maintain cellular homeostasis. However, as the impact of Hepatitis C virus (HCV) infection on hepatocyte autophagy and its effect on HCV replication remain unclear, we examined them. HCV infection suppressed late-stage autophagy and increased Rubicon. siRNA-...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Shiode, Yuto, Hikita, Hayato, Tanaka, Satoshi, Shirai, Kumiko, Doi, Akira, Sakane, Sadatsugu, Kai, Yugo, Nakabori, Tasuku, Yamada, Ryoko, Kodama, Takahiro, Narumi, Ryohei, Sakamori, Ryotaro, Eguchi, Hidetoshi, Tomonaga, Takeshi, Tatsumi, Tomohide, Takehara, Tetsuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498609/
https://ncbi.nlm.nih.gov/pubmed/32943718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72294-y
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