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Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents–A drug repurposing strategy

Phenothiazines (PTZs) have been used for the antipsychotic drugs for centuries. However, some of these PTZs have been reported to exhibit antitumor effects by targeting various signaling pathways in vitro and in vivo. Thus, this study was aimed at exploiting trifluoperazine, one of PTZs, to develop...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Wu, Chia-Hsien, Bai, Li-Yuan, Tsai, Ming-Hsui, Chu, Po-Chen, Chiu, Chang-Fang, Chen, Michael Yuanchien, Chiu, Shih-Jiuan, Chiang, Jo-Hua, Weng, Jing-Ru
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899727/
https://ncbi.nlm.nih.gov/pubmed/27277973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27540
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