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Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents–A drug repurposing strategy

Phenothiazines (PTZs) have been used for the antipsychotic drugs for centuries. However, some of these PTZs have been reported to exhibit antitumor effects by targeting various signaling pathways in vitro and in vivo. Thus, this study was aimed at exploiting trifluoperazine, one of PTZs, to develop...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wu, Chia-Hsien, Bai, Li-Yuan, Tsai, Ming-Hsui, Chu, Po-Chen, Chiu, Chang-Fang, Chen, Michael Yuanchien, Chiu, Shih-Jiuan, Chiang, Jo-Hua, Weng, Jing-Ru
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899727/
https://ncbi.nlm.nih.gov/pubmed/27277973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27540
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