Lactase non-persistence is directed by DNA variation-dependent epigenetic aging

Inability to digest lactose due to lactase non-persistence is a common trait in adult mammals, with the exception of certain human populations that exhibit lactase persistence. It is not clear how the lactase gene can be dramatically downregulated with age in most individuals, but remains active in...

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Pubblicato in:Nat Struct Mol Biol
Autori principali: Labrie, Viviane, Buske, Orion J, Oh, Edward, Jeremian, Richie, Ptak, Carolyn, Gasiūnas, Giedrius, Maleckas, Almantas, Petereit, Rūta, Žvirbliene, Aida, Adamonis, Kęstutis, Kriukienė, Edita, Koncevičius, Karolis, Gordevičius, Juozas, Nair, Akhil, Zhang, Aiping, Ebrahimi, Sasha, Oh, Gabriel, Šikšnys, Virginijus, Kupčinskas, Limas, Brudno, Michael, Petronis, Arturas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899171/
https://ncbi.nlm.nih.gov/pubmed/27159559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3227
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