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CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1

The CD5 transmembrane glycoprotein functions as a co-receptor in the signaling pathway linking T-cell antigen receptor (TCR) engagement to activation and differentiation. Although CD5 effects on TCR signaling have been shown to be primarily inhibitory, the underlying mechanisms remain unclear. In vi...

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Détails bibliographiques
Publié dans:Int J Mol Med
Auteurs principaux: DONG, BAOXIA, SOMANI, ALLY-KHAN, LOVE, PAUL E., ZHENG, XUAN, CHEN, XIEQUN, ZHANG, JINYI
Format: Artigo
Langue:Inglês
Publié: D.A. Spandidos 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899029/
https://ncbi.nlm.nih.gov/pubmed/27221212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2016.2592
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