T cell activation is reduced by the catalytically inactive form of protein tyrosine phosphatase SHP-2

Src-homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is a ubiquitously expressed cytosolic tyrosine phosphatase implicated in many different signaling pathways involving cytokine receptors and T and B cell receptors; however, the precise functional role of SHP-2 in T cell signaling is not...

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Veröffentlicht in:Int J Clin Exp Med
Hauptverfasser: Dong, Baoxia, Gao, Yubo, Zheng, Xuan, Gao, Guangxun, Gu, Hongtao, Chen, Xiequn, Zhang, Jinyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483852/
https://ncbi.nlm.nih.gov/pubmed/26131287
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