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Unravelling the structural plasticity of stretched DNA under torsional constraint

Regions of the genome are often held under torsional constraint. Nevertheless, the influence of such constraint on DNA–protein interactions during genome metabolism is still poorly understood. Here using a combined optical tweezers and fluorescence microscope, we quantify and explain how torsional c...

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Pubblicato in:Nat Commun
Autori principali: King, Graeme A., Peterman, Erwin J. G., Wuite, Gijs J. L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897764/
https://ncbi.nlm.nih.gov/pubmed/27263853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11810
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