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Unravelling the structural plasticity of stretched DNA under torsional constraint

Regions of the genome are often held under torsional constraint. Nevertheless, the influence of such constraint on DNA–protein interactions during genome metabolism is still poorly understood. Here using a combined optical tweezers and fluorescence microscope, we quantify and explain how torsional c...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: King, Graeme A., Peterman, Erwin J. G., Wuite, Gijs J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897764/
https://ncbi.nlm.nih.gov/pubmed/27263853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11810
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