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Autoimmune diseases — connecting risk alleles with molecular traits of the immune system

Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for autoimmune diseases. However, for almost all loci, understanding of the mechanisms leading to autoimmunity remains limited, and most variants that are likely to be causal are in non-coding regions of the genome...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Rev Genet
Prif Awduron: Gutierrez-Arcelus, Maria, Rich, Stephen S., Raychaudhuri, Soumya
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896831/
https://ncbi.nlm.nih.gov/pubmed/26907721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg.2015.33
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