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Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome
Internal ribosome entry sites (IRESs) mediate cap-independent translation of viral mRNAs. Using electron cryo-microscopy of a single specimen, we present five ribosome structures formed with the Taura syndrome virus IRES and translocase eEF2•GTP bound with sordarin. The structures suggest a trajecto...
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| Publié dans: | eLife |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
eLife Sciences Publications, Ltd
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4896748/ https://ncbi.nlm.nih.gov/pubmed/27159452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14874 |
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