Mechanism of ribosome rescue by ArfA and RF2

ArfA rescues ribosomes stalled on truncated mRNAs by recruiting release factor RF2, which normally binds stop codons to catalyze peptide release. We report two 3.2 Å resolution cryo-EM structures – determined from a single sample – of the 70S ribosome with ArfA•RF2 in the A site. In both states, the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Demo, Gabriel, Svidritskiy, Egor, Madireddy, Rohini, Diaz-Avalos, Ruben, Grant, Timothy, Grigorieff, Nikolaus, Sousa, Duncan, Korostelev, Andrei A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2017
Gaiak:
Biochemistry
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378476/
https://ncbi.nlm.nih.gov/pubmed/28300532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23687
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