An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK

A broadly known method to stimulate the growth potential of axons is to elevate intracellular levels of cAMP, however the cellular pathway(s) that mediate this are not known. Here we identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Hao, Yan, Frey, Erin, Yoon, Choya, Wong, Hetty, Nestorovski, Douglas, Holzman, Lawrence B, Giger, Roman J, DiAntonio, Aaron, Collins, Catherine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2016
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896747/
https://ncbi.nlm.nih.gov/pubmed/27268300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14048
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