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An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK

A broadly known method to stimulate the growth potential of axons is to elevate intracellular levels of cAMP, however the cellular pathway(s) that mediate this are not known. Here we identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hao, Yan, Frey, Erin, Yoon, Choya, Wong, Hetty, Nestorovski, Douglas, Holzman, Lawrence B, Giger, Roman J, DiAntonio, Aaron, Collins, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896747/
https://ncbi.nlm.nih.gov/pubmed/27268300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14048
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