An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK

A broadly known method to stimulate the growth potential of axons is to elevate intracellular levels of cAMP, however the cellular pathway(s) that mediate this are not known. Here we identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured...

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Vydáno v:eLife
Hlavní autoři: Hao, Yan, Frey, Erin, Yoon, Choya, Wong, Hetty, Nestorovski, Douglas, Holzman, Lawrence B, Giger, Roman J, DiAntonio, Aaron, Collins, Catherine
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896747/
https://ncbi.nlm.nih.gov/pubmed/27268300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14048
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