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A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function
Shank and SAPAP (synapse-associated protein 90/postsynaptic density-95–associated protein) are two highly abundant scaffold proteins that directly interact with each other to regulate excitatory synapse development and plasticity. Mutations of SAPAP, but not other reported Shank PDZ domain binders,...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4896714/ https://ncbi.nlm.nih.gov/pubmed/27185935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523265113 |
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