Coronavirus receptor switch explained from the stereochemistry of protein–carbohydrate interactions and a single mutation

Hemagglutinin-esterases (HEs) are bimodular envelope proteins of orthomyxoviruses, toroviruses, and coronaviruses with a carbohydrate-binding “lectin” domain appended to a receptor-destroying sialate-O-acetylesterase (“esterase”). In concert, these domains facilitate dynamic virion attachment to cel...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Bakkers, Mark J. G., Zeng, Qinghong, Feitsma, Louris J., Hulswit, Ruben J. G., Li, Zeshi, Westerbeke, Aniek, van Kuppeveld, Frank J. M., Boons, Geert-Jan, Langereis, Martijn A., Huizinga, Eric G., de Groot, Raoul J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896708/
https://ncbi.nlm.nih.gov/pubmed/27185912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519881113
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