The Murine Coronavirus Hemagglutinin-esterase Receptor-binding Site: A Major Shift in Ligand Specificity through Modest Changes in Architecture

The hemagglutinin-esterases (HEs), envelope glycoproteins of corona-, toro- and orthomyxoviruses, mediate reversible virion attachment to O-acetylated sialic acids (O-Ac-Sias). They do so through concerted action of distinct receptor-binding (“lectin”) and receptor-destroying sialate O-acetylesteras...

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Main Authors: Langereis, Martijn A., Zeng, Qinghong, Heesters, Balthasar, Huizinga, Eric G., de Groot, Raoul J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266934/
https://ncbi.nlm.nih.gov/pubmed/22291594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002492
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