Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity

Human beta1-coronavirus (β1CoV) OC43 emerged relatively recently through a single zoonotic introduction. Like related animal β1CoVs, OC43 uses 9-O-acetylated sialic acid as receptor determinant. β1CoV receptor binding is typically controlled by attachment/fusion spike protein S and receptor-binding/...

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Udgivet i:Cell Host Microbe
Main Authors: Bakkers, Mark J.G., Lang, Yifei, Feitsma, Louris J., Hulswit, Ruben J.G., de Poot, Stefanie A.H., van Vliet, Arno L.W., Margine, Irina, de Groot-Mijnes, Jolanda D.F., van Kuppeveld, Frank J.M., Langereis, Martijn A., Huizinga, Eric G., de Groot, Raoul J.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104930/
https://ncbi.nlm.nih.gov/pubmed/28279346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.02.008
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