Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation

BACKGROUND: TFEB (transcription factor EB) regulates metabolic homeostasis through its activation of lysosomal biogenesis following its nuclear translocation. TFEB activity is inhibited by mTOR phosphorylation, which signals its cytoplasmic retention. To date, the temporal relationship between alter...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Marin Zapata, Paula Andrea, Beese, Carsten Jörn, Jünger, Anja, Dalmasso, Giovanni, Brady, Nathan Ryan, Hamacher-Brady, Anne
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896000/
https://ncbi.nlm.nih.gov/pubmed/27268034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2388-9
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