Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation

BACKGROUND: TFEB (transcription factor EB) regulates metabolic homeostasis through its activation of lysosomal biogenesis following its nuclear translocation. TFEB activity is inhibited by mTOR phosphorylation, which signals its cytoplasmic retention. To date, the temporal relationship between alter...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Marin Zapata, Paula Andrea, Beese, Carsten Jörn, Jünger, Anja, Dalmasso, Giovanni, Brady, Nathan Ryan, Hamacher-Brady, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896000/
https://ncbi.nlm.nih.gov/pubmed/27268034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2388-9
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