AMPK activation and metabolic reprogramming by tamoxifen through estrogen receptor-independent mechanisms suggests new uses for this therapeutic modality in cancer treatment

Tamoxifen is the most widely used adjuvant chemotherapeutic for the treatment of estrogen receptor (ER) positive breast cancer, yet a large body of clinical and preclinical data indicates that tamoxifen can modulate multiple cellular processes independently of ER status. Here, we describe the ER-ind...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Daurio, Natalie A., Tuttle, Stephen W., Worth, Andrew J., Song, Ethan Y., Davis, Julianne M., Snyder, Nathaniel W., Blair, Ian A., Koumenis, Constantinos
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895922/
https://ncbi.nlm.nih.gov/pubmed/27020861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2197
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