AMPK activation and metabolic reprogramming by tamoxifen through estrogen receptor-independent mechanisms suggests new uses for this therapeutic modality in cancer treatment

Tamoxifen is the most widely used adjuvant chemotherapeutic for the treatment of estrogen receptor (ER) positive breast cancer, yet a large body of clinical and preclinical data indicates that tamoxifen can modulate multiple cellular processes independently of ER status. Here, we describe the ER-ind...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Daurio, Natalie A., Tuttle, Stephen W., Worth, Andrew J., Song, Ethan Y., Davis, Julianne M., Snyder, Nathaniel W., Blair, Ian A., Koumenis, Constantinos
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895922/
https://ncbi.nlm.nih.gov/pubmed/27020861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2197
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