Auto-Assembling Detoxified Staphylococcus aureus Alpha-Hemolysin Mimicking the Wild-Type Cytolytic Toxin

Staphylococcus aureus alpha-hemolysin (Hla) assembles into heptameric pores on the host cell membrane, causing lysis, apoptosis, and junction disruption. Herein, we present the design of a newly engineered S. aureus alpha-toxin, HlaPSGS, which lacks the predicted membrane-spanning stem domain. This...

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Vydáno v:Clin Vaccine Immunol
Hlavní autoři: Fiaschi, Luigi, Di Palo, Benedetta, Scarselli, Maria, Pozzi, Clarissa, Tomaszewski, Kelly, Galletti, Bruno, Nardi-Dei, Vincenzo, Arcidiacono, Letizia, Mishra, Ravi P. N., Mori, Elena, Pallaoro, Michele, Falugi, Fabiana, Torre, Antonina, Fontana, Maria Rita, Soriani, Marco, Bubeck Wardenburg, Juliane, Grandi, Guido, Rappuoli, Rino, Ferlenghi, Ilaria, Bagnoli, Fabio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895005/
https://ncbi.nlm.nih.gov/pubmed/27030589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00091-16
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