Auto-Assembling Detoxified Staphylococcus aureus Alpha-Hemolysin Mimicking the Wild-Type Cytolytic Toxin

Staphylococcus aureus alpha-hemolysin (Hla) assembles into heptameric pores on the host cell membrane, causing lysis, apoptosis, and junction disruption. Herein, we present the design of a newly engineered S. aureus alpha-toxin, HlaPSGS, which lacks the predicted membrane-spanning stem domain. This...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Clin Vaccine Immunol
Autors principals: Fiaschi, Luigi, Di Palo, Benedetta, Scarselli, Maria, Pozzi, Clarissa, Tomaszewski, Kelly, Galletti, Bruno, Nardi-Dei, Vincenzo, Arcidiacono, Letizia, Mishra, Ravi P. N., Mori, Elena, Pallaoro, Michele, Falugi, Fabiana, Torre, Antonina, Fontana, Maria Rita, Soriani, Marco, Bubeck Wardenburg, Juliane, Grandi, Guido, Rappuoli, Rino, Ferlenghi, Ilaria, Bagnoli, Fabio
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895005/
https://ncbi.nlm.nih.gov/pubmed/27030589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00091-16
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars