Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer

Expansion of the polyglutamine (polyQ) track of the Huntingtin (HTT) protein above 36 is associated with a sharply enhanced risk of Huntington’s disease (HD). Although there is general agreement that HTT toxicity resides primarily in N-terminal fragments such as the HTT exon1 protein, there is no co...

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Pubblicato in:PLoS One
Autori principali: Sahoo, Bankanidhi, Arduini, Irene, Drombosky, Kenneth W., Kodali, Ravindra, Sanders, Laurie H., Greenamyre, J. Timothy, Wetzel, Ronald
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894636/
https://ncbi.nlm.nih.gov/pubmed/27271685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155747
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