Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

BACKGROUND: Ras homolog gene family, member A (RhoA)/Rho-associated coiled-coil forming protein kinase signaling is a key pathway in multiple types of solid organ fibrosis, including intestinal fibrosis. However, the pleiotropic effects of RhoA/Rho-associated coiled-coil forming protein kinase signa...

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Detaylı Bibliyografya
Yayımlandı:Inflamm Bowel Dis
Asıl Yazarlar: Johnson, Laura A., Rodansky, Eva S., Haak, Andrew J., Larsen, Scott D., Neubig, Richard R., Higgins, Peter D. R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893808/
https://ncbi.nlm.nih.gov/pubmed/24280883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.MIB.0000437615.98881.31
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