Adaptive and Acquired Resistance to EGFR Inhibitors Converge on the MAPK Pathway

Both adaptive and acquired resistance significantly limits the efficacy of the epidermal growth factor receptor (EGFR) kinase inhibitors. However, the distinct or common mechanisms of adaptive and acquired resistance have not been fully characterized. Here, through systematic modeling of erlotinib r...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Ma, Pengfei, Fu, Yujie, Chen, Minjiang, Jing, Ying, Wu, Jie, Li, Ke, Shen, Ying, Gao, Jian-Xin, Wang, Mengzhao, Zhao, Xiaojing, Zhuang, Guanglei
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893648/
https://ncbi.nlm.nih.gov/pubmed/27279914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.14409
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