Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer

Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution. Here, we sequence a unique cohort of multiple synchronous lung cancers (MSLCs) to determine the relat...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ma, Pengfei, Fu, Yujie, Cai, Mei-Chun, Yan, Ying, Jing, Ying, Zhang, Shengzhe, Chen, Minjiang, Wu, Jie, Shen, Ying, Zhu, Liang, Chen, Hong-Zhuan, Gao, Wei-Qiang, Wang, Mengzhao, Gu, Zhenyu, Bivona, Trever G., Zhao, Xiaojing, Zhuang, Guanglei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634994/
https://ncbi.nlm.nih.gov/pubmed/29018192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00963-0
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