Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer

Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution. Here, we sequence a unique cohort of multiple synchronous lung cancers (MSLCs) to determine the relat...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Ma, Pengfei, Fu, Yujie, Cai, Mei-Chun, Yan, Ying, Jing, Ying, Zhang, Shengzhe, Chen, Minjiang, Wu, Jie, Shen, Ying, Zhu, Liang, Chen, Hong-Zhuan, Gao, Wei-Qiang, Wang, Mengzhao, Gu, Zhenyu, Bivona, Trever G., Zhao, Xiaojing, Zhuang, Guanglei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634994/
https://ncbi.nlm.nih.gov/pubmed/29018192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00963-0
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