Repression of the antioxidant NRF2 pathway in premature aging

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, invariably fatal premature aging disorder. The disease is caused by constitutive production of progerin, a mutant form of the nuclear architectural protein lamin A, leading, through unknown mechanisms, to diverse morphological, epigenetic and ge...

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Udgivet i:Cell
Main Authors: Kubben, Nard, Zhang, Weiqi, Wang, Lixia, Voss, Ty C., Yang, Jiping, Qu, Jing, Liu, Guang-Hui, Misteli, Tom
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893198/
https://ncbi.nlm.nih.gov/pubmed/27259148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.017
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