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Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford Progeria Syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A, one of the major architectural elements of the mammalian cell nucleus1–4. The HGPS mutation activates an aberrant cryptic splice site in the lamin A pre-mRNA, leading...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1351119/ https://ncbi.nlm.nih.gov/pubmed/15750600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1204 |
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