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5′-β,γ-CHF-ATP Diastereomers: Synthesis and Fluorine-Mediated Selective Binding by c-Src Protein Kinase
The first preparation of the individual β,γ-CHF-ATP stereoisomers 12a and 12b is reported. Configurationally differing solely by the orientation of the C–F fluorine, 12a and 12b have discrete (31)P (202 MHz, pH 10.9, Δδ(Pα) 6 Hz, Δδ(Pβ) 4 Hz) and (19)F NMR (470 MHz, pH 9.8, Δδ(F) 25 Hz) spectral sig...
Gardado en:
| Publicado en: | Org Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4892180/ https://ncbi.nlm.nih.gov/pubmed/25781066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol503765n |
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