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5′-β,γ-CHF-ATP Diastereomers: Synthesis and Fluorine-Mediated Selective Binding by c-Src Protein Kinase

The first preparation of the individual β,γ-CHF-ATP stereoisomers 12a and 12b is reported. Configurationally differing solely by the orientation of the C–F fluorine, 12a and 12b have discrete (31)P (202 MHz, pH 10.9, Δδ(Pα) 6 Hz, Δδ(Pβ) 4 Hz) and (19)F NMR (470 MHz, pH 9.8, Δδ(F) 25 Hz) spectral sig...

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Bibliografiske detaljer
Udgivet i:Org Lett
Main Authors: Hwang, Candy S., Kung, Alvin, Kashemirov, Boris A., Zhang, Chao, McKenna, Charles E.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892180/
https://ncbi.nlm.nih.gov/pubmed/25781066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol503765n
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