Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury–associated coagulopathy in mice

Cardiolipin (CL) is an anionic phospholipid located exclusively in the mitochondrial inner membrane. Its presence in blood indicates mitochondrial damage and release from injured cells. Here, we report the detection of CL-exposed brain-derived mitochondrial microparticles (mtMPs) at 17 547 ± 2677/μL...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Zhao, Zilong, Wang, Min, Tian, Ye, Hilton, Tristan, Salsbery, Breia, Zhou, Eric Z., Wu, Xiaoping, Thiagarajan, Perumal, Boilard, Eric, Li, Min, Zhang, Jianning, Dong, Jing-fei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891956/
https://ncbi.nlm.nih.gov/pubmed/27002118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-12-688838
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