Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury–associated coagulopathy in mice

Cardiolipin (CL) is an anionic phospholipid located exclusively in the mitochondrial inner membrane. Its presence in blood indicates mitochondrial damage and release from injured cells. Here, we report the detection of CL-exposed brain-derived mitochondrial microparticles (mtMPs) at 17 547 ± 2677/μL...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Zhao, Zilong, Wang, Min, Tian, Ye, Hilton, Tristan, Salsbery, Breia, Zhou, Eric Z., Wu, Xiaoping, Thiagarajan, Perumal, Boilard, Eric, Li, Min, Zhang, Jianning, Dong, Jing-fei
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2016
Teme:
Thrombosis and Hemostasis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891956/
https://ncbi.nlm.nih.gov/pubmed/27002118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-12-688838
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